Three Vaccines Use Other Viruses to Protect Against COVID-19

More than 5 million people worldwide have had their lives cut short by COVID-19, and the number keeps rising as many countries experience another wave of transmission.

The best defense against this disease is a vaccine, experts say.

Since the outbreak was first reported in 2019, the best scientists all over the world have been working on a vaccine to protect against SARS CoV 2, the virus that causes COVID-19. The acronym stands for “severe acute respiratory syndrome coronavirus 2” to distinguish it from the first SARS outbreak in 2003.

Historically, when scientists make vaccines, they have used a live virus that is so weak it can’t reproduce, or they use a dead virus. When these weakened or inactive viruses are injected into the body, the body recognizes them as intruders, produces antibodies and fights them off.

Polio vaccines have used both weakened live viruses as well as dead ones with enormous success. The Global Polio Eradication Initiative reports that polio cases were reduced by 99.9% between 1988, when the global effort to eliminate polio was started, and 2021. The U.S. Centers for Disease Control and Prevention reports that without the global polio vaccination program, more than 18 million people who are currently healthy would have been paralyzed by the virus.

As of December 6, three children in the entire world have contracted the wild polio virus in 2021.

Three of the vaccines developed against COVID-19 are vector vaccines. A vector is simply a delivery system. In this case, scientists use an adenovirus — a cold virus, for example — to deliver a fragment of the coronavirus. The fragment is a gene from a spike on the crown of the coronavirus. This trains the body to fight off any other similar infections, including COVID-19.

The spike cannot infect someone with the coronavirus.

The Oxford-AstraZeneca vaccine uses a chimpanzee virus, not a human one. The Johnson & Johnson and Sputnik V vaccines use human adenoviruses. J&J uses a rare adenovirus. Sputnik V uses the same virus in its first dose. In its second dose, Sputnik V uses a common adenovirus that some people might be immune to. For this reason, many scientists are concerned that Sputnik V may not be an effective vaccine.

Once injected, the viruses enter the cells and start to produce the spike protein, but not COVID-19. Then, the body mounts an attack.

Dr. Andrea Cox, a professor with a specialty in immunology at the Johns Hopkins University School of Medicine, says our bodies don’t just mount an immune response to the adenovirus, but they also produce an immune response to the spike protein from the coronavirus. In this way, the body learns to fight off the coronavirus if it sees it again.

The World Health Organization has authorized use of the AstraZeneca and Johnson & Johnson vaccines but not Sputnik V. The WHO says it needs more data from the Sputnik V trials.

Cox says the AstraZeneca and Johnson & Johnson vaccines are preferred because they have been given to hundreds of millions of people worldwide. Scientists have more information about their side effects and their immune responses than Sputnik V’s simply because Sputnik has been used far less frequently and there are fewer international studies that have assessed it.

Another issue with Sputnik V, Cox says, is “that the data are not showing the kinds of efficacy rates that we would like to see in a vaccine.”

Some scientists expect COVID-19 to be with us for three to four years. But even with the best scientists in the world working on vaccines, they are concerned that as the virus continues to infect unvaccinated people and mutate, at some point, the vaccines we have now won’t be able to offer full protection against COVID-19.

Source: Voice of America

Nobel Prizes Awarded in Pandemic-Curtailed Local Ceremonies

Three 2021 Nobel Prize laureates said Monday that climate change is the biggest threat facing the world — yet they remain optimistic — as this year’s winners began receiving their awards at scaled-down local ceremonies adapted for pandemic times.

For a second year, COVID-19 has scuttled the traditional formal banquet in Stockholm attended by winners of the prizes in chemistry, physics, medicine, literature and economics, which were announced in October. The Nobel Peace Prize is awarded separately in Oslo, Norway.

Literature laureate Abdulrazak Gurnah was first to get his prize in a lunchtime ceremony Monday at the Swedish ambassador’s grand Georgian residence in central London.

Ambassador Mikaela Kumlin Granit said the U.K.-based Tanzanian author had been awarded the Nobel Prize in literature for his “uncompromising and compassionate penetration of the effects of colonialism and the fate of the refugee in the gulf between cultures and continents.”

“Customarily you would receive the prize from the hands of His Majesty, the king of Sweden,” she told Gurnah at the ceremony attended by friends, family and colleagues. “However, this year you will be celebrated with a distance forced upon us because of the pandemic.”

Gurnah, who grew up on the island of Zanzibar and arrived in England as an 18-year-old refugee in the 1960s, has drawn on his experiences for 10 novels, including “Memory of Departure,” “Pilgrims Way,” “Afterlives” and “Paradise.” He has said migration is “not just my story — it’s a phenomenon of our times.”

Italian physics laureate Giorgio Parisi was receiving his prize at a ceremony in Rome. U.S.-based physics laureate Syukuro Manabe, chemistry laureate David W.C. MacMillan and economic sciences laureate Joshua D. Angrist will be given their medals and diplomas in Washington.

MacMillan, German physics prize winner Klaus Hasselmann and economics prize winner Guido Imbens, who is Dutch but lives in the United States, had a joint virtual news conference Monday where they were asked what they consider the biggest problem facing humanity and what they worry about most. All three answered climate change, with Imbens calling it the world’s “overarching problem.”

“Climate change is something which is clearly going to have a large impact on society,” MacMillan said. “But at the same time given the science, given the call to arms amongst scientists, I really feel more optimism. And I feel there’s a real moment happening with scientists moving towards trying to solve this problem.”

“I would bet on that fact that we would solve this problem,” MacMillan said.

Hasselmann, whose work on climate change won him the prize, said he’s more hopeful because the world’s youth and movements like Fridays for the Future “have picked up the challenge and are getting across the message to the public that we have to act and respond to the problem.”

Hasselmann said he’s more optimistic now about climate change than 20 or 30 years ago.

Imbens said he also is disturbed that misinformation, especially about COVID-19 and vaccines, is splitting society apart. He recalled growing up in the Netherlands and nearly everyone agreed on the need for the polio vaccine.

“And yet, here we don’t seem to have found a way of making these decisions that we can all live with,” Imbens said. “And that’s clearly made it much harder to deal with the pandemic.”

More ceremonies will be held throughout the week in Germany and the United States. On Friday — the anniversary of the death of prize founder Albert Nobel — there will be a celebratory ceremony at Stockholm City Hall for a local audience, including King Carl XVI Gustav and senior Swedish royals.

A Nobel Prize comes with a diploma, a gold medal and a $1.5 million (10-million krona) cash award, which is shared if there are multiple winners.

The Nobel Peace Prize is awarded in Oslo because Nobel wanted it that way, for reasons he kept to himself. A ceremony is due to be held there Friday for the winners — journalists Maria Ressa of the Philippines and Dmitry Muratov of Russia.

The Norwegian news agency NTB said the festivities would be scaled down, with fewer guests and participants required to wear face masks. Norway has seen an uptick in cases of the new omicron variant, and a spokesman for the Norwegian Nobel Committee told NTB it was “in constant contact with the health authorities in Oslo.”

Source: Voice of America

US Condemns Militant Attack in Mali that Killed 31

The United States “strongly condemns” a militant attack on a bus in central Mali that killed at least 31 people and wounded 17, the State Department said Sunday.

Unidentified gunmen on Friday opened fire on the bus as it traveled from the village of Songho to a market in Bandiagara, 10 kilometers away.

The villages sit in the heart of the Mopti region, an epicenter of violence in Mali fueled by insurgents linked to al-Qaida and the Islamic State group.

“The United States strongly condemns the attack on civilians on Saturday near Bandiagara, Mali, which left 31 dead and 17 injured,” State Department spokesman Ned Price said in a written statement.

“We extend our deepest condolences to the Malian people and will continue to partner with them in their pursuit of a safe, prosperous, and democratic future,” Price said.

Jihadist attacks have surged across Africa’s Sahel region, killing thousands and displacing millions across Mali, Burkina Faso and Niger.

Source: Voice of America

Twin Explosions Rock UN Camps in Mali

Two explosions rocked U.N. camps in the northern Mali city of Gao on Sunday, causing damage but no casualties, AFP journalists at the scene said.

The early morning blasts shook the barracks of the U.N. mission in Mali, called MINUSMA, forcing the occupants to take refuge in shelters for two hours.

The French army reported only material damage, but had no information on the possible perpetrators of the blasts.

MINUSMA spokeswoman Myriam Dessables told AFP that two other camps in the north had been targeted with mortar fire on Saturday, causing no damage.

The latest violence in the West African country comes after 31 people were killed in an attack on Friday by suspected jihadists near the central town of Bandiagara.

Mali has been struggling to contain an Islamist insurgency that first erupted in the north in 2012 and has since claimed thousands of military and civilian lives.

Despite the presence of thousands of French and U.N. troops, the conflict has engulfed central Mali and spread to neighboring Burkina Faso and Niger.

France, the former colonial power in Mali, has said it will reduce its troop numbers in the Sahel.

It also said it is planning to transfer troops from Kidal, Tessalit and Timbuktu to Gao and Menaka, closer to the turbulent “three-borders” zone near Burkina Faso and Niger.

Source: Voice of America

Stuck Jet Stream, La Nina Causing Weird Weather

America’s winter wonderland is starting out this season as anything but traditional.

The calendar says December, but for much of the country, temperatures beckon for sandals. Umbrellas, if not arks, are needed in the Pacific Northwest, while snow shovels are gathering cobwebs in the Rockies.

Meteorologists attribute the latest batch of record-shattering weather extremes to a stuck jet stream and the effects of a La Nina weather pattern from cooling waters in the equatorial Pacific.

It’s still fall astronomically, but winter starts December 1 for meteorologists. This year, no one told the weather that.

On Thursday, 65 weather stations across the nation set record high temperature marks for December 2, including Springfield, Missouri, hitting 24 Celsius (75 degrees Fahrenheit) and Roanoke, Virginia, 22 Celsius (72 degrees Fahrenheit). Cheyenne, Wyoming, and Billings, Montana, broke long-time high-temperature records by 6 degrees.

Parts of Canada and Montana have seen their highest December temperatures in recorded history. On Friday, parts of South Carolina and Georgia hit record highs.

In Washington state, Seattle, Bellingham and Quillayute all set 90-day fall records for rainfall. Bellingham was doused by nearly 60 centimeters (nearly 24 inches) of rain. The Olympic and Cascade mountains got hit harder, with more than 127 centimeters (50 inches) in three months, according to the National Weather Service. Forks, Washington, received more rain in 90 days than Las Vegas gets in 13 years.

On top of that, there is a blizzard warning on Hawaii’s Big Island summits with up to 30.5 centimeters (12 inches) of snow expected and wind gusts of more than 161 kilometers per hour (100 miles per hour).

Meantime, snow has gone missing in Colorado. Before this year, the latest first measurable snowfall on record in Denver was November 21, in 1934. There’s a slight possibility of snow Monday night, according to the weather service. Yet, with no snow since April 22, this is the third-longest stretch the city has gone without it.

Stationary stream

One big factor: The jet stream — the river of air that moves weather from west to east on a roller coaster-like path — has just been stuck. That means low pressure on one part of the stream is bringing rain to the Pacific Northwest, while high pressure hovering over about two-thirds of the nation produces dry and warmer weather, said Brian Hurley, a senior meteorologist at the weather service’s Weather Prediction Center in College Park, Maryland.

If the jet stream moves more or bends differently, rain and other extreme weather won’t be as concentrated, Hurley said.

This is a typical weather pattern with a natural La Nina weather oscillation, he said. The flip side of El Nino, a La Nina is a cooling of parts of the central Pacific Ocean that changes weather patterns across the globe. La Ninas tend to bring more rain to the Pacific Northwest and make the South drier and warmer.

These bouts of extreme weather happen more frequently as the world warms, said meteorologist Jeff Masters, founder of Weather Underground who now works at Yale Climate Connections.

In Boulder, Colorado, meteorologist Bob Henson enjoyed a rare December bike ride on Thursday.

Still, “there’s a lot of angst about the lack of snow,” he said. “It puts you in a psychic quandary. You enjoy the warm weather while keeping in mind it’s not good for Earth to be warming.”

Source: Voice of America

Cameroon Launches Vaccination Campaign to Contain Measles Outbreak

Cameroon has begun a measles vaccination drive on its northern border with Nigeria after several dozen children were found with the infection at a demobilization center. Cameroon says most of those infected are children of former fighters fleeing Boko Haram terrorism.

A mother comforts her 13-month-old baby in Kanuri, a language spoken in Meri, a commercial town on Cameroon’s northern border with Nigeria. The 24-year-old mother says she hopes her child’s life will be saved after inoculation against measles, as promised by vaccination agents deployed to her town.

Prosper Essomba is the Cameroon government’s chief medical officer in Meri. He is supervising a vaccination campaign launched Friday against measles.

Essomba says he first inoculated his 1-year-old son to convince people that vaccination will protect their children from a measles outbreak. He says about 100 vaccination teams have been deployed in all villages around Meri to vaccinate all children with ages from 6 months to 9 years against measles and rubella. Essomba says about 67,000 children are targeted in the weeklong free vaccination campaign.

Essomba said vaccination teams have been sent to the Disarmament and Demobilization center in Meri. He said children of all people fleeing from Boko Haram strongholds on the border with Nigeria should be inoculated.

Yaya Ali, the highest government official in Meri says he asked the government of Cameroon to immediately organize vaccinations when more than a dozen cases of measles were detected in Meri within a week. He says the first measles case was reported in a 4-year-old child at the Disarmament, Demobilization and Reintegration Center at Meri. He says it is imperative for everyone to make sure that all children in Meri are protected by receiving the measles, mumps and rubella or MMR vaccine.

Ali said besides vaccinating children against measles and rubella, inoculation teams verify vaccination cards to make sure parents are keeping up with the vaccination schedules of their children. Essomba said it is important to administer all missed vaccine doses as soon as it is feasible.

Cameroon says several dozen measles infections have been reported within the past two weeks in nine other hospitals in Cameroon’s Far North region, where Meri is located. The government says many more people may be infected, since less than 30% of the population visits conventional health facilities.

Cameroon reports that 79 of its 190 district hospitals were affected by measles epidemics in 2020, with about 1,500 confirmed measle infections. The country’s Public Health Ministry says 74% of the confirmed cases were in people who were not vaccinated.

Health officials say when COVID-19 was reported in the central African state in March 2020 parents were afraid to take their children to hospitals for vaccinations since hospitals are also COVID-19 test and treatment centers.

Measles is a disease caused by a highly contagious virus that is spread through the air by breathing, coughing, or sneezing.

However, the World Health Organization says two injections of vaccine can prevent measles. The WHO says the vaccine is safe and effective and has been in use since the 1960s.

Cameroon’s last major measles outbreak was reported from February 2010 to July 2011.

Source: Voice of America